15727-65-8
15727-65-8 structure
- Name: 1-Ethynylnaphthalene
- Chemical Name: 1-ethynylnaphthalene
- CAS Number: 15727-65-8
- Molecular Formula: C12H8
- Molecular Weight: 152.19200
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
- Create Date: 2018-06-18 17:21:22
- Modify Date: 2025-08-25 19:46:49
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1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1.
| Name | 1-ethynylnaphthalene |
|---|---|
| Synonyms |
1-(ethynyl)naphthalene
1-naphthalene-acetylene Naphthalene,1-ethynyl naphthylacetylene (1-naphthyl)acetylene MFCD02093737 ethynyl-naphthalene |
| Description | 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1. |
|---|---|
| Related Catalog | |
| Target |
P450 1B1[1] |
| In Vitro | 1-Ethynylnaphthalene, selective inhibitor of cytochrome P450 IB1, does not affect 2-hydroxylation but inhibits 4-hydroxylation by 38%. At higher concentrations, 1-Ethynylnaphthalene inhibits 2-hydroxylation of 2-Hydroxylation of estradiol (E2) by ~30% and 4-hydroxylation of E2 by up to 80%[1]. |
| References |
| Density | 1.070 g/mL at 25ºC(lit.) |
|---|---|
| Boiling Point | 270.4ºC at 760 mmHg |
| Molecular Formula | C12H8 |
| Molecular Weight | 152.19200 |
| Flash Point | 106.3ºC |
| Exact Mass | 152.06300 |
| LogP | 2.82110 |
| Vapour Pressure | 0.0114mmHg at 25°C |
| Index of Refraction | n20/D 1.6500(lit.) |
| Storage condition | 2-8℃ |
| Precursor 10 | |
|---|---|
| DownStream 10 | |
![naphtho[2,1-b]thiophene structure](https://image.chemsrc.com/caspic/415/233-02-3.png)
![Benzo[c]picene structure](https://image.chemsrc.com/caspic/340/217-37-8.png)
| HS Code | 2902909090 |
|---|---|
| Summary | 2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0% |