4-(hydroxymethyl)-d-phenylalanine

Names

[ Name ]:
4-(hydroxymethyl)-d-phenylalanine

[Synonym ]:
(R)-2-Amino-3-[4-(hydroxymethyl)phenyl]propionic acid
4-(Hydroxymethyl)-D-phenylalanine
D-Phenylalanine,4-(hydroxymethyl)

Biological Activity

[Description]:

4-(Hydroxymethyl)-D-phenylalanine is a phenylalanine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-874.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₃NO₃

[ Molecular Weight ]:
195.21500

[ Exact Mass ]:
195.09000

[ PSA ]:
83.55000

[ LogP ]:
0.83360

[ Vapour Pressure ]:
5.14E-07mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Tetrapeptide tyrosine kinase inhibitors. Enantioselective synthesis of p-hydroxymethyl-L-phenylalanine, incorporation into a tetrapeptide, and subsequent elaboration into p-(R,S-hydroxyphosphonomethyl)-L-phenylalanine.

Int. J. Pept. Protein Res. 44(5) , 457-65, (1994)

A convenient enantioselective synthesis of p-hydroxymethyl-L-phenylalanine was developed which produces a 4/1 ratio of L/D enantiomers resulting from a chiral phase-transfer-catalyzed alkylation. This...

Analogs of arginine vasopressin modified in position 3 with (R)-alpha-hydroxymethylphenylalanine.

J. Pept. Res. 53(5) , 554-9, (1999)

This study describes the synthesis and some pharmacological properties of three new analogs of arginine vasopressin (AVP) substituted in position 3 with (R)-alpha-hydroxymethylphenylalanine ([R]-HmPhe...

DALDA analogues containing alpha-hydroxymethylamino acids.

Acta Biochim. Pol. 48(4) , 1121-4, (2001)

To evaluate the role of aromatic amino-acids residues, four analogues of the mu-selective opioid peptide agonist DALDA (H-Tyr-D-Arg-Phe-Lys-NH2) containing the amphiphilic, a,a-disubstituted amino aci...