pyrante

Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2].

Research Areas >> Infection

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Parasites[1][2].

Pyrantel (10 nM-10 µM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity[1][2]. Cell Viability Assay[1] Cell Line: A. suum Concentration: 10 nM-10 µM Incubation Time: 72 h Result: Inhibited A. suum with a pEC50 value of 7.24. Cell Viability Assay[2] Cell Line: N. americanus Concentration: 0-168.2 M (0-100 µg/mL) Incubation Time: 72 h Result: Inhibited third-stage larvae and adult of N. americanus with IC50 values of 2.0 and 7.6 mg/mL, respectively.

Pyrantel (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%[2]. Animal Model: Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected)[2]. Dosage: 10 mg/kg Administration: Oral administration; single. Result: Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.

MOLECULAR FORMULA :

C11-H14-N2-S

MOLECULAR WEIGHT :

206.33

WISWESSER LINE NOTATION :

T6N CN AUTJ B1U1- BT5SJ& C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

170 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

175 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

ANBCB3 Antibiotics and Chemotherapy (Basel). (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.17- 1971- Volume(issue)/page/year: 30,1,1981