PBB3

Names

[ Name ]:
PBB3

[Synonym ]:
PBB-3
2-{(1E,3E)-4-[6-(Methylamino)-3-pyridinyl]-1,3-butadien-1-yl}-1,3-benzothiazol-6-ol
6-Benzothiazolol, 2-[(1E,3E)-4-[6-(methylamino)-3-pyridinyl]-1,3-butadien-1-yl]-

Biological Activity

[Description]:

PBB3, a selective PET ligand, recognizes tau pathology in Alzheimer's disease brains, where dystrophic neurites and diffuse neurofibrils are more clearly detected Tangles with calcification[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Maiko Ono, et al. Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies. Brain. 2017 Mar 1;140(3):764-780.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
572.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₅N₃OS

[ Molecular Weight ]:
309.39

[ Flash Point ]:
300.0±32.9 °C

[ Exact Mass ]:
309.093567

[ LogP ]:
3.30

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.797

Related Compounds

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