Boc-L-Cyclobutylglycine

Names

[ Name ]:
Boc-L-Cyclobutylglycine

[Synonym ]:
Boc-L-Cyclobutylglycine
Cyclobutaneacetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αS)-
(S)-tert-Butoxycarbonylamino-cyclobutyl-acetic acid
(2S)-Cyclobutyl({[(2-methyl-2-propanyl)oxy]carbonyl}amino)acetic acid

Biological Activity

[Description]:

Boc-L-cyclobutylglycine is a glycine derivative that can be used for PI3K inhibitor synthesis[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[References]

[1]. Kim YS, et al. Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies. Bioorg Med Chem. 2021 Sep 1;45:116312.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
379.1±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₉NO₄

[ Molecular Weight ]:
229.273

[ Flash Point ]:
183.1±23.2 °C

[ Exact Mass ]:
229.131409

[ PSA ]:
75.63000

[ LogP ]:
2.03

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.501

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%