CHLORO(TRIETHYLPHOSPHINE)GOLD(I)
Names
[ CAS No. ]:
15529-90-5
[ Name ]:
CHLORO(TRIETHYLPHOSPHINE)GOLD(I)
[Synonym ]:
Gold,chloro(triethylphosphine)
[Au(PEt3)Cl]
chloro(triethylphosphine)-gol
TRIETHYLPHOSPHINEGOLD I CHLORIDE
chloro(triethylphosphine)gold
[AuCl(PEt3)]
PEt3 gold(I) chloro complex
EINECS 239-572-3
MFCD00013205
Triethylphosphineaurous chloride
triethylphosphinegold
Chemical & Physical Properties
[ Boiling Point ]:
210ºC0.03 mm Hg(lit.)
[ Melting Point ]:
84-86ºC(lit.)
[ Molecular Formula ]:
C6H15AuClP
[ Molecular Weight ]:
350.57700
[ Flash Point ]:
27.2ºC
[ Exact Mass ]:
350.02700
[ PSA ]:
13.59000
[ LogP ]:
3.21500
[ Appearance of Characters ]:
crystal | white to pink
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MD5431000
- CHEMICAL NAME :
- Gold, chloro(triethylphosphine)-
- CAS REGISTRY NUMBER :
- 15529-90-5
- LAST UPDATED :
- 199112
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C6-H15-Au-Cl-P
- MOLECULAR WEIGHT :
- 350.60
- WISWESSER LINE NOTATION :
- G-AU-UP3&3&3
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 79 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 68 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 92560 ug/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 46280 ug/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Cells - not otherwise specified
- DOSE/DURATION :
- 37500 nmol/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 34,3243,1985
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301 + H311 + H331-H315-H319-H335
[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T: Toxic;
[ Risk Phrases ]:
R23/24/25
[ Safety Phrases ]:
26-28-36/37/39-45
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
MD5431000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
Synthetic Route
Articles
J. Inorg. Biochem. 38(2) , 95-100, (1990)
New compounds having the formula [L-Au-PEt3]Cl (where L = imidazolidine-2-thione(Imt) and 1,3-Diazinane-2-thione(Diaz)) are synthesized. They are characterized by elemental analysis, infrared, 13C and...
Inhibition of human phospholipase C by aurothiomalate and (triethylphosphine) gold complexes.Arzneimittelforschung 42(3) , 328-33, (1992)
The effect of several gold complexes on the activity of phospholipase C from human blood platelets was studied in vitro. Aurothiomalate and auranofin--2 agents used for the chrysotherapy of rheumatoid...
The structural flexibility of ferric cytochrome c: regulation of the spin-state equilibrium by an anti-arthritic gold(I) compound at neutral pH.FEBS Lett. 116(2) , 227-30, (1980)