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Pomalidomide-5-OH

Names

[ CAS No. ]:
1547162-41-3

[ Name ]:
Pomalidomide-5-OH

[Synonym ]:
4-Amino-2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-1H-isoindole-1,3(2H)-dione
CC-17368
MFCD32199595
1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
2JD83JK9RC
UNII:2JD83JK9RC

Biological Activity

[Description]:

Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Matthew Hoffmann, et al. Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol. 2013 Feb;71(2):489-501.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
633.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H11N3O5

[ Molecular Weight ]:
289.24

[ Flash Point ]:
336.6±31.5 °C

[ Exact Mass ]:
289.069885

[ LogP ]:
-1.24

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.725

[ Storage condition ]:
2-8°C

Related Compounds