Thalidomide-5-OH

Names

[ Name ]:
Thalidomide-5-OH

[Synonym ]:
5-Hydroxythalidomide

Biological Activity

[Description]:

Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon

[References]

[1]. Megan G Marks, et al. Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation. Biol Pharm Bull. 2002 May;25(5):597-604.

Chemical & Physical Properties

[ Density]:
1.611g/cm3

[ Boiling Point ]:
600ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₁₀N₂O₅

[ Molecular Weight ]:
274.22900

[ Flash Point ]:
316.7ºC

[ Exact Mass ]:
274.05900

[ PSA ]:
107.27000

[ LogP ]:
0.00720

[ Index of Refraction ]:
1.679

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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