Neurokinin Receptor (393-407), rat

Names

[ CAS No. ]:
153607-26-2

[ Name ]:
Neurokinin Receptor (393-407), rat

Biological Activity

[Description]:

Neurokinin Receptor (393-407), rat (SPR393–407) is a rat neurokinin 1 receptor (NK1R) fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

NK1


[In Vitro]

Neurokinin Receptor (393-407), rat (10 pM) 抑制 50% 的 125I-SPR393-407 与抗血清结合。

[References]

[1]. Nathan JD, et al. Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2001 Nov;281(5):G1322-8.  

[2]. Vigna SR, et al. Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells. J Neurosci. 1994 Feb;14(2):834-45.  

Chemical & Physical Properties

[ Molecular Formula ]:
C72H113N17O26S2

[ Molecular Weight ]:
1696.90

Related Compounds