2,6-Dichloro-N-phenylaniline

Names

[ Name ]:
2,6-Dichloro-N-phenylaniline

[Synonym ]:
2,6-DICHLORODIPHENYLAMINE
N-Phenyl-2,6-dichloroaniline
2,6-Dichloro-N-phenylaniline
EINECS 239-349-0
MFCD00269648
N-(2,6-Dichlorophenyl)aniline
Benzenamine, 2,6-dichloro-N-phenyl-
Diclofenac Impurity 6

Biological Activity

[Description]:

2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Makoto Urai,et al. Potent Drugs That Attenuate anti-Candida Albicans Activity of Fluconazole and Their Possible Mechanisms of Action. J Infect Chemother. 2014 Oct;20(10):612-5.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
309.8±32.0 °C at 760 mmHg

[ Melting Point ]:
50-53 °C(lit.)

[ Molecular Formula ]:
C₁₂H₉Cl₂N

[ Molecular Weight ]:
238.113

[ Flash Point ]:
141.2±25.1 °C

[ Exact Mass ]:
237.011200

[ PSA ]:
12.03000

[ LogP ]:
4.77

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.650

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H410

[ Precautionary Statements ]:
P273-P305 + P351 + P338-P501

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 3077 9 / PGIII

[ WGK Germany ]:
3

[ HS Code ]:
2921440000

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2921440000

[ Summary ]:
2921440000. diphenylamine and its derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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