L-701252

Names

[ Name ]:
L-701252

[Synonym ]:
L-701,252
Tocris-0705

Biological Activity

[Description]:

L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral ischaemia[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

NMDA receptor[1]

[In Vivo]

L-701252 (50 mg/kg; i.p.) provides a small non-significant protection[1]. Animal Model: 3-Months Male Mongolian gerbils (60 g)[1] Dosage: 50 mg/kg Administration: i.p. Result: Provided a small non-significant protection.

[References]

[1]. Stone TW. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci. 2000;21(4):149-154.

[2]. Widdowson PS, et al. Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Brain Res. 1996;738(2):236-242.

Chemical & Physical Properties

[ Density]:
1.573g/cm3

[ Boiling Point ]:
437.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₁₀ClNO₃

[ Molecular Weight ]:
263.67600

[ Flash Point ]:
218.3ºC

[ Exact Mass ]:
263.03500

[ PSA ]:
70.16000

[ LogP ]:
2.47980

[ Vapour Pressure ]:
2.03E-08mmHg at 25°C

[ Index of Refraction ]:
1.694

[ Storage condition ]:
-20°C

Precursor & DownStream

Precursor

DownStream

Related Compounds

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