7,8-Didehydrocimigenol

Names

[ Name ]:
7,8-Didehydrocimigenol

[Synonym ]:
(1S,2R,3R,7R,9S,12R,14R,17R,18R,19R,21R,22S)-22-(2-Hydroxy-2-propanyl)-3,8,8,17,19-pentamethyl-23,24-dioxaheptacyclo[19.2.1.01,18.03,17.04,14.07,12.012,14]tetracos-4-ene-2,9-diol
10,12a-Epoxy-2H,5H-cyclopropa[1',8'a]naphth[2',1':4,5]indeno[2,1-b]oxepin-2,13-diol, 1,3,4,6,7,7a,7b,8,9,10,11,13,13a,15,15a-pentadecahydro-11-(1-hydroxy-1-methylethyl)-1,1,7a,8,13a-pentamethyl-, (2S,4aR,5aR,7aR,7bR,8R,10R,11S,12aS,13R,13aR,15aR)-

Biological Activity

[Description]:

7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

[References]

[1]. Mun L, et al. 7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ in human endothelial cells. Food Chem Toxicol. 2011 Jan;49(1):166-72.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
621.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₄₆O₅

[ Molecular Weight ]:
486.683

[ Flash Point ]:
329.8±31.5 °C

[ Exact Mass ]:
486.334534

[ LogP ]:
5.31

[ Vapour Pressure ]:
0.0±4.1 mmHg at 25°C

[ Index of Refraction ]:
1.601

Related Compounds

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