150972-72-8

150972-72-8 structure

Name: 7,8-Didehydrocimigenol
Chemical Name: 7,8-Didehydrocimigenol
CAS Number: 150972-72-8
Molecular Formula: C₃₀H₄₆O₅
Molecular Weight: 486.683
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2018-12-16 18:27:56
Modify Date: 2024-01-15 18:30:13
7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis[1].

Name	7,8-Didehydrocimigenol
Synonyms	(1S,2R,3R,7R,9S,12R,14R,17R,18R,19R,21R,22S)-22-(2-Hydroxy-2-propanyl)-3,8,8,17,19-pentamethyl-23,24-dioxaheptacyclo[19.2.1.01,18.03,17.04,14.07,12.012,14]tetracos-4-ene-2,9-diol 10,12a-Epoxy-2H,5H-cyclopropa[1',8'a]naphth[2',1':4,5]indeno[2,1-b]oxepin-2,13-diol, 1,3,4,6,7,7a,7b,8,9,10,11,13,13a,15,15a-pentadecahydro-11-(1-hydroxy-1-methylethyl)-1,1,7a,8,13a-pentamethyl-, (2S,4aR,5aR,7aR,7bR,8R,10R,11S,12aS,13R,13aR,15aR)-

Description	7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
References	[1]. Mun L, et al. 7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ in human endothelial cells. Food Chem Toxicol. 2011 Jan;49(1):166-72.