8-Bromo-2'-deoxyadenosine

Names

[ Name ]:
8-Bromo-2'-deoxyadenosine

[Synonym ]:
8-Br-dA
(2R,3S,5R)-5-(6-Amino-8-bromo-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
8-Bromo-9-(2'-deoxyribofuranosyl)adenine
8-bromo-2'-deoxy-adenosine
8-bromo-deoxyadenosine
8-bromo-2'-deoxydenosine
8-BROMO-2'-DEOXY-D-ADENOSINE

Biological Activity

[Description]:

8-Bromo-2'-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.3g/cm3

[ Boiling Point ]:
671ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₂BrN₅O₃

[ Molecular Weight ]:
330.14

[ Flash Point ]:
359.6ºC

[ Exact Mass ]:
329.01200

[ PSA ]:
119.31000

[ LogP ]:
0.39290

[ Appearance of Characters ]:
Powder | White to Yellow

[ Vapour Pressure ]:
6.41E-19mmHg at 25°C

[ Index of Refraction ]:
1.898

[ Water Solubility ]:
Soluble in DMSO or DMF

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R24

[ Safety Phrases ]:
36-45-53

8-Bromo-2'-deoxyadenosine

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Click to get detail synthetic route

Related Compounds