NaV1.7 inhibitor-1

Names

[ Name ]:
NaV1.7 inhibitor-1

Biological Activity

[Description]:

NaV1.7 inhibitor-1 is an efficacious voltage-gated sodium channel (NaV) 1.7 inhibitor with an IC50 of 0.6 nM for hNaV1.7, exhibits 80-fold selectivity versus hNaV1.5[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

[Target]

IC50: 0.6 nM (hNaV1.7)[1]

[References]

[1]. Sun S, Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-GatedSodium Channel (NaV) 1.7 with Potent Analgesic Activity. J Med Chem. 2019 Jan 24;62(2):908-927.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₀FNO₄S

[ Molecular Weight ]:
435.55

Related Compounds

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