Arcaine sulfate

Names

[ Name ]:
Arcaine sulfate

[Synonym ]:
1,4-DIGUANIDINOBUTANE SULFATE SALT
ARCAINE SULPHATE
1,4-diguanidinobutane sulfate
N,N'''-butanediyl-di-guanidine,sulfate
ARCAIN SULFATE
MFCD00050545
N,N'''-Butandiyl-di-guanidin,Sulfat
ARCAINE SULFATE SALT
Butane-1,4-diguanidium sulfate
1,1'-tetramethylenediguanidine sulphate
usafa-5080
Prestwick_1059
arcaine sulfate
arcaine sulfate crystalline

Biological Activity

[Description]:

Arcaine (sulfate) is a glutamate NMDA receptor inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Huang MJ, et al. Structure-activity analysis of guanidine group in agmatine for brain agmatinase. Ann N Y Acad Sci. 2003 Dec;1009:52-63.

Chemical & Physical Properties

[ Density]:
1.37g/cm3

[ Boiling Point ]:
408.9ºC at 760mmHg

[ Melting Point ]:
291°C (dec.)

[ Molecular Formula ]:
C₆H₁₈N₆O₄S

[ Molecular Weight ]:
270.31

[ Flash Point ]:
201.1ºC

[ Exact Mass ]:
270.11100

[ PSA ]:
206.78000

[ LogP ]:
1.54260

[ Vapour Pressure ]:
6.76E-07mmHg at 25°C

[ Storage condition ]:
Store at RT

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF6550000

CAS REGISTRY NUMBER :: 14923-17-2

LAST UPDATED :: 199012

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H16-N6.H2-O4-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MF6550000

[ HS Code ]:
2925290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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