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Estrone sulfamate

Names

[ CAS No. ]:
148672-09-7

[ Name ]:
Estrone sulfamate

[Synonym ]:
estrone sulfamate
Estra-1,3,5(10)-trien-17-one,3-((aminosulfonyl)oxy)
Emate compound
3-sulfamoyloxyestra-1,3,5(10)-trien-17-one
Estra-1,3,5(10)-trien-17-one-3-sulfamate
Estrone-3-sulfamate
estrone-3-o-sulfamate
3-((Aminosulfonyl)oxy)estra-1,3,5(10)-trien-17-one
Oestrone-3-O-sulphamate
17-oxo-estra-1,3,5(10)-trien-3-yl sulfamate
EMATE

Biological Activity

[Description]:

Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent steroid sulfatase (STS) inhibitor. Estrone O-sulfamate has inhibitory activity for STS in a placental microsomes (P.M.) preparation and in MCF-7 cells with IC50 values of 18 nM and 0.83 nM, respectively. Estrone O-sulfamate can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Estrone O-sulfamate (Estrone 3-O-sulfamate) 在胎盘微粒体 (P.M.) 制剂和 MCF-7 细胞中对 STS 具有抑制活性，IC50 值分别为 18 nM 和 0.83 nM[1]。

[References]

[1]. L W Lawrence Woo, et al. Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors. Bioorg Med Chem. 2012 Apr 15;20(8):2506-19.  

Chemical & Physical Properties

[ Density]:
1.314g/cm3

[ Boiling Point ]:
530.9ºC at 760mmHg

[ Melting Point ]:
195-197ºC

[ Molecular Formula ]:
C18H23NO4S

[ Molecular Weight ]:
349.44500

[ Flash Point ]:
274.9ºC

[ Exact Mass ]:
349.13500

[ PSA ]:
94.84000

[ LogP ]:
4.47520

[ Vapour Pressure ]:
2.35E-11mmHg at 25°C

[ Index of Refraction ]:
1.595

Precursor & DownStream

Precursor

DownStream

Related Compounds