148672-09-7

148672-09-7 structure

Name: Estrone sulfamate
Chemical Name: [(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] sulfamate
CAS Number: 148672-09-7
Molecular Formula: C₁₈H₂₃NO₄S
Molecular Weight: 349.44500
Catalog: Research Areas Cancer
Create Date: 2016-09-20 03:19:17
Modify Date: 2024-01-09 16:50:22
Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent steroid sulfatase (STS) inhibitor. Estrone O-sulfamate has inhibitory activity for STS in a placental microsomes (P.M.) preparation and in MCF-7 cells with IC50 values of 18 nM and 0.83 nM, respectively. Estrone O-sulfamate can be used for the research of cancer[1].

Name	[(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] sulfamate
Synonyms	estrone sulfamate Estra-1,3,5(10)-trien-17-one,3-((aminosulfonyl)oxy) Emate compound 3-sulfamoyloxyestra-1,3,5(10)-trien-17-one Estra-1,3,5(10)-trien-17-one-3-sulfamate Estrone-3-sulfamate estrone-3-o-sulfamate 3-((Aminosulfonyl)oxy)estra-1,3,5(10)-trien-17-one Oestrone-3-O-sulphamate 17-oxo-estra-1,3,5(10)-trien-3-yl sulfamate EMATE

Description	Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent steroid sulfatase (STS) inhibitor. Estrone O-sulfamate has inhibitory activity for STS in a placental microsomes (P.M.) preparation and in MCF-7 cells with IC50 values of 18 nM and 0.83 nM, respectively. Estrone O-sulfamate can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Estrone O-sulfamate (Estrone 3-O-sulfamate) 在胎盘微粒体 (P.M.) 制剂和 MCF-7 细胞中对 STS 具有抑制活性，IC50 值分别为 18 nM 和 0.83 nM[1]。
References	[1]. L W Lawrence Woo, et al. Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors. Bioorg Med Chem. 2012 Apr 15;20(8):2506-19.

Precursor 2
53-16-7 1189-71-5
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