Ac-Leu-Leu-Norleucinol

Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST)[1].

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

Calpain[1]

Ac-Leu-Leu-Norleucinol (10 mg/kg, 20 mg/kg; i.p.; single dose) effectively prevents Acetaminophen (HY-66005)-induced acute liver injury in mice model[1]. Animal Model: Acute liver injury model induced by Acetaminophen (APAP) in C57BL/6 mice (18-22 g)[1] Dosage: 10 mg/kg, 20 mg/kg; accompanied with 300 mg/kg APAP (i.p.) Administration: Intraperitoneal injection; collected tissue samples 24 hr after Result: Significantly reduced APAP-induced stem cell necrosis and lowered the level of glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST). Injection alone did not cause pathological changes in the liver.

[1]. Song Fuyong, et al. Application of calpain inhibitor ALLN in preventing and treating acetaminophen induced acute liver damage: China, CN108939046[P]. 2018-12-07.