148333-42-0
148333-42-0 structure
- Name: Ac-Leu-Leu-Norleucinol
- Chemical Name: Ac-Leu-Leu-Norleucinol
- CAS Number: 148333-42-0
- Molecular Formula: C20H37N3O5
- Molecular Weight: 399.52
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
- Create Date: 2022-11-18 16:57:17
- Modify Date: 2023-02-02 17:20:53
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Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST)[1].
| Name | Ac-Leu-Leu-Norleucinol |
|---|
| Description | Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST)[1]. |
|---|---|
| Related Catalog | |
| Target |
Calpain[1] |
| In Vivo | Ac-Leu-Leu-Norleucinol (10 mg/kg, 20 mg/kg; i.p.; single dose) effectively prevents Acetaminophen (HY-66005)-induced acute liver injury in mice model[1]. Animal Model: Acute liver injury model induced by Acetaminophen (APAP) in C57BL/6 mice (18-22 g)[1] Dosage: 10 mg/kg, 20 mg/kg; accompanied with 300 mg/kg APAP (i.p.) Administration: Intraperitoneal injection; collected tissue samples 24 hr after Result: Significantly reduced APAP-induced stem cell necrosis and lowered the level of glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST). Injection alone did not cause pathological changes in the liver. |
| References |
| Molecular Formula | C20H37N3O5 |
|---|---|
| Molecular Weight | 399.52 |