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KT185

Names

[ CAS No. ]:
1472640-86-0

[ Name ]:
KT185

Biological Activity

[Description]:

KT185 is an orally-bioavailable, brain-penetrant and selective ABHD6 inhibitor, with an IC50 0.21 nM in Neuro2A cells[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL

[Target]

IC50: ABHD6 (0.21 nM in Neuro2A cells)[1].


[References]

[1]. Hsu KL, et al. Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). J Med Chem. 2013 Nov 14;56(21):8270-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H33N5O2

[ Molecular Weight ]:
519.64

Safety Information

[ RIDADR ]:
NONH for all modes of transport