CID-46943215

Names

[ Name ]:
CID-46943215

[Synonym ]:
Benzamide, 2-[2-[(4-bromophenyl)amino]-2-oxoethoxy]-N-[2-(methylphenylamino)-2-oxoethyl]-
2-{2-[(4-Bromophenyl)amino]-2-oxoethoxy}-N-{2-[methyl(phenyl)amino]-2-oxoethyl}benzamide
CID-46943215

Biological Activity

[Description]:

ML266 is glucocerebrosidase (GCase) molecule chaperone with IC50 of 2.5 µM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the activity of GCase. ML266 dose not inhibit the GCase enzyme’s action. ML266 has the potential for the research of gaucher disease[1].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Rogers S, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7].

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
724.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₂BrN₃O₄

[ Molecular Weight ]:
496.35

[ Flash Point ]:
391.8±32.9 °C

[ Exact Mass ]:
495.079376

[ LogP ]:
3.47

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.659

Related Compounds

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