Cetrorelix Acetate

Names

[ Name ]:
Cetrorelix Acetate

Biological Activity

[Description]:

Cetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. Sequence: N-acetyl-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-Ser-Tyr-{Cit}-Leu-Arg-Pro-Ala-NH2.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GNRH Receptor

Research Areas >> Neurological Disease

Peptides

[Target]

IC50: 1.21 nM GnRH[1].

[In Vitro]

Cetrorelix Acetate inhibits growth of ES-2 cell line at 1000 ng/ml. Cetrorelix Acetate has comparable antiproliferative effects as GnRH-I agonists indicating that the dichotomy of GnRH-I agonists and antagonists might not apply to the GnRH-I system in cancer cells[2].

[References]

[1]. Beckers T et al. Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal Biochem. 1997 Aug 15;251(1):17-23.

[2]. Gründker C et al. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod Biol Endocrinol. 2003 Oct 7;1:65.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₇₂H₉₆ClN₁₇O₁₆

[ Molecular Weight ]:
1491.09000

[ Exact Mass ]:
1489.69000

[ PSA ]:
532.97000

[ LogP ]:
6.02320

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H361

[ Precautionary Statements ]:
P281

[ RIDADR ]:
NONH for all modes of transport

Articles

Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency.

Hum. Reprod. 30(3) , 608-15, (2015)

Is ovarian tissue cryopreservation using vitrification followed by in vitro activation (IVA) of dormant follicles a potential approach for infertility treatment of patients with primary ovarian insuff...

Ovarian stimulation and in-vitro fertilization outcomes of cancer patients undergoing fertility preservation compared to age matched controls: a 17-year experience.

J. Assist. Reprod. Genet. 32(4) , 587-96, (2015)

To compare the in-vitro fertilization (IVF) outcomes of cancer patients who underwent oocyte retrieval and embryo/oocyte cryopreservation prior to gonadotoxic therapy to those of age and time-matched ...

Sperm morphological normality under high magnification predicts laboratory and clinical outcomes in couples undergoing ICSI.

Hum. Fertil. (Camb.) 18 , 81-6, (2015)

The objective of this study was to evaluate whether 'motile sperm organelle morphology examination' (MSOME) is correlated with the outcome of ICSI. A total of 14400 spermatozoa from 72 couples undergo...

Related Compounds

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