(Des-Gly10,tBu-D-Gly6,Pro-NHEt9)-LHRH trifluoroacetate salt

Names

[ Name ]:
(Des-Gly10,tBu-D-Gly6,Pro-NHEt9)-LHRH trifluoroacetate salt

[Synonym ]:
Lecirelin (Dalmarelin) Acetate
5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-3-methyl-D-valyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-3-methyl-D-valyl-L-leucyl-L-arginyl-N-ethyl-
Lecirelin Acetate
Supergestran
GLP-HIS-TRP-SER-TYR-TLE-LEU-ARG-PRO-NHET

Biological Activity

[Description]:

Lecirelin is a synthetic gonadotropin-releasing hormone (GnRH) analogue. Lecirelin is widely used for the research of bovine ovarian follicular cysts[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GNRH Receptor

Research Areas >> Cancer

Research Areas >> Endocrinology

[In Vitro]

Lecirelin (2.07 μM) significantly increases the tension and frequency of contractions in preovulatory follicles (PF), small follicular cysts (FC-S), and large follicular cysts (FC-L)[1]. Lecirelin increases the strips from preovulatory follicles contract significantly more than strips from cysts[1].

[References]

[1]. Rizzo A et al. Bovine ovarian follicular cysts: in vitro effects of lecirelin, a GnRH analogue. Theriogenology. 2010 Dec;74(9):1559-69.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₅₉H₈₄N₁₆O₁₂

[ Molecular Weight ]:
1209.398

[ Exact Mass ]:
1208.645508

[ PSA ]:
429.04000

[ LogP ]:
0.23

[ Index of Refraction ]:
1.678

[ Storage condition ]:
-20°C