VU 0467485

Names

[ CAS No. ]:
1451994-10-7

[ Name ]:
VU 0467485

[Synonym ]:
5-Amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
Thieno[2,3-c]pyridazine-6-carboxamide, 5-amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethyl-

Biological Activity

[Description]:

VU0467485 (VU-0467485, AZ13713945) is potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator with EC50 of 78.8 nM (hM4); possesses robust in vitro M4 PAM potency across species and in vivo efficacy in preclinical models of schizophrenia.

[References]

References 1. Wood MR, et al. ACS Med Chem Lett. 2016 Dec 16;8(2):233-238. 2. Melancon BJ, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2296-2301. 3. Deng X, et al. ChemMedChem. 2018 Dec 27. doi: 10.1002/cmdc.201800710. View Related Products by Target mAChR

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₇H₁₇FN₄O₂S

[ Molecular Weight ]:
360.406

[ Exact Mass ]:
360.105621

[ LogP ]:
3.11

[ Index of Refraction ]:
1.660

Related Compounds

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