Comins' Reagent
Names
[ CAS No. ]:
145100-51-2
[ Name ]:
Comins' Reagent
[Synonym ]:
2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide
N-(5-Chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide
2-(N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulf
N-(5-Chloro-2-pyridyl)triflimide
MFCD00191833
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonyl)imide
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide)
Comins Triflating
2-[N,N-Bis(Trifluoromethylsulphonyl)amino]-5-chloropyridine
Comins' Reagent
Methanesulfonamide, N-(5-chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]-
N-(5-Chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide
Chemical & Physical Properties
[ Density]:
1.9±0.1 g/cm3
[ Boiling Point ]:
358.3±52.0 °C at 760 mmHg
[ Melting Point ]:
45-47 °C(lit.)
[ Molecular Formula ]:
C7H3ClF6N2O4S2
[ Molecular Weight ]:
392.683
[ Flash Point ]:
170.5±30.7 °C
[ Exact Mass ]:
391.912689
[ PSA ]:
101.17000
[ LogP ]:
2.68
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.499
[ Storage condition ]:
Keep Cold
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ HS Code ]:
2935009090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2935009090
[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
Articles
Angew. Chem. Int. Ed. Engl. 53(10) , 2692-5, (2014)
Leiodermatolide is an antimitotic macrolide isolated from the marine sponge Leiodermatium sp. whose potentially novel tubulin-targeting mechanism of action makes it an exciting lead for anticancer dru...
Tetrahedron Lett. 33 , 6299, (1992)
Tetrahedron Lett. 44 , 9185, (2003)