Sodium taurocholate

Names

[ CAS No. ]:
145-42-6

[ Name ]:
Sodium taurocholate

[Synonym ]:
Taurine, N-choloyl-, monosodium salt
monosodium N-choloyltaurinate
sodium N-choloyltaurinate
Sodium 2-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl}amino)ethanesulfonate
MFCD00013050
ethanesulfonic acid, 2-[[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)
Taurocholic Acid Sodium Salt from Bovine Bile
froM Bovine Bile
taurocholatesodiumsalt
Sodium 2-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate
Ethanesulfonic acid, 2-[[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)
taurocholic acid sodium salt
Sodium taurocholate
taurocholatesodium
Bile Salts (10 g)
TAUROCHOLIC ACID NA-SALT
2-{[(3α,5β,7α,8ξ,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]amino}éthanesulfonate de sodium
taurocholate sodium
taurocholate sodiuM sal
Natrium-2-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl}amino)ethansulfonat
Sodium Taurocholate from Bovine Bile
Natrium-2-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethansulfonat
Taurocholic acid
Monosodium 2-(((3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)ethanesulfonate
EINECS 205-653-7
Sodium 2-{[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate
taurocholate sodium salt
taurochlolic acid sodium salt
Ethanesulfonic acid, 2-(((3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, monosodium salt
Taurocholic sodium
2-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-diméthylhexadécahydro-1H-cyclopenta[a]phénanthrén-17-yl]pentanoyl}amino)éthanesulfonate de sodium
Taurine, N-choloyl-, sodium salt
Sodium taurocholate hydrate

Biological Activity

[Description]:

Taurocholic acid sodium (Sodium taurocholate; N-Choloyltaurine sodium) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Immunoregulation effect[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

Microbial Metabolite

Human Endogenous Metabolite

[References]

[1]. Caiyun Wang, et al. Effects of taurocholic acid on immunoregulation in mice. Int Immunopharmacol. 2013 Feb;15(2):217-22.

Chemical & Physical Properties

[ Melting Point ]:
230 °C

[ Molecular Formula ]:
C₂₆H₄₄NNaO₇S

[ Molecular Weight ]:
537.685

[ Exact Mass ]:
537.273621

[ PSA ]:
155.37000

[ LogP ]:
3.49720

[ Index of Refraction ]:
23 ° (C=3, H2O)

[ Water Solubility ]:
> 250 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WX0400000

CHEMICAL NAME :: Taurine, N-choloyl-, sodium salt

CAS REGISTRY NUMBER :: 145-42-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C26-H44-N-O7-S.Na

MOLECULAR WEIGHT :: 537.76

WISWESSER LINE NOTATION :: L E5 B666TJ A1 DQ E1 FY1&2VM2SWO KQ OQ &-NA- &42/32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 78,32,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80529 No. of Facilities: 126 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 3026 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80529 No. of Facilities: 52 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 741 (estimated) No. of Female Employees: 544 (estimated)

Safety Information

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
WX0400000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

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Sensing of dietary triacylglycerol in the proximal small intestine results in physiological, hormonal and behavioural responses. However, the exact physiological pathways linking intestinal fat sensin...

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AAPS J. 16(4) , 875-83, (2014)

The effect of food intake on the release and degradation of peptide drugs from solid lipid particles is unknown and was therefore investigated in vitro using different fed state media in a lipolysis m...

Identification of a novel hypocholesterolemic protein, major royal jelly protein 1, derived from royal jelly.

PLoS ONE 9(8) , e105073, (2014)

Royal jelly (RJ) intake lowers serum cholesterol levels in animals and humans, but the active component in RJ that lowers serum cholesterol level and its molecular mechanism are unclear. In this study...