DQP-26

Names

[ CAS No. ]:
1449373-99-2

[ Name ]:
DQP-26

Biological Activity

[Description]:

DQP-26 is a potent NMDAR negative allosteric modulator with IC50 values of 0.77 μM and 0.44 μM for GluN2C and GluN2D, respectively. DQP-26 has the potential for NMDAR-associated neurological disease research[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Michael P D'Erasmo, et al. Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor. ACS Chem Neurosci. 2023 Sep 6;14(17):3059-3076.  

Chemical & Physical Properties

[ Molecular Formula ]:
C28H21Cl2N3O4

[ Molecular Weight ]:
534.39

Related Compounds