Lubeluzole

Names

[ Name ]:
Lubeluzole

[Synonym ]:
Prosynap
Lubeluzole

Biological Activity

[Description]:

Lubeluzole is a neuroprotective anti-ischemic compound. Lubeluzole, but not its (-)-R-isomer, protects against sensorimotor deficits provoked by photochemical stroke in rats. Lubeluzole inhibited glutamate-stimulated guanosine 3',5'-cyclic monophosphate production with an IC50 of 37 nM. Lubeluzole also has the potential for developing a novel class of antibacterial adjuvants endowed with spasmolytic activity[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Cavalluzzi MM, et al. Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies. Pharmacol Rep. 2021;73(1):172-184.

[2]. Lesage AS, et al. Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway. J Pharmacol Exp Ther. 1996;279(2):759-766.

Chemical & Physical Properties

[ Density]:
1.327g/cm3

[ Boiling Point ]:
579.8ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₅F₂N₃O₂S

[ Molecular Weight ]:
433.51500

[ Flash Point ]:
304.5ºC

[ Exact Mass ]:
433.16400

[ PSA ]:
77.07000

[ LogP ]:
3.85290

[ Vapour Pressure ]:
2.75E-14mmHg at 25°C

[ Index of Refraction ]:
1.632

MSDS

Click to get detail MSDS

Related Compounds

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