TWIK-1/TREK-1-IN-3

Names

[ Name ]:
TWIK-1/TREK-1-IN-3

Biological Activity

[Description]:

TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 9.74 μM (TREK-1/TREK-1), 16.5 μM (TWIK-1/TREK-1)[1]

[References]

[1]. Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139.. .

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₇F₃N₂O₂

[ Molecular Weight ]:
372.43

Related Compounds

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