1440532-33-1
1440532-33-1 structure
- Name: TWIK-1/TREK-1-IN-3
- Chemical Name: TWIK-1/TREK-1-IN-3
- CAS Number: 1440532-33-1
- Molecular Formula: C19H27F3N2O2
- Molecular Weight: 372.43
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2024-10-01 10:01:55
- Modify Date: 2024-10-01 10:01:55
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TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects[1].
| Name | TWIK-1/TREK-1-IN-3 |
|---|
| Description | TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects[1]. |
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| Related Catalog | |
| Target |
IC50: 9.74 μM (TREK-1/TREK-1), 16.5 μM (TWIK-1/TREK-1)[1] |
| References |
| Molecular Formula | C19H27F3N2O2 |
|---|---|
| Molecular Weight | 372.43 |