TWIK-1/TREK-1-IN-2

Names

[ CAS No. ]:
1440532-32-0

[ Name ]:
TWIK-1/TREK-1-IN-2

Biological Activity

[Description]:

TWIK-1/TREK-1-IN-2 (Compound 2g) is a TWIK-1/TREK-1 inhibitor. TWIK-1/TREK-1-IN-2 inhibits TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 10.13 μM and 15.5 μM. TWIK-1/TREK-1-IN-2 is an antidepressant[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H29F3N2O2

[ Molecular Weight ]:
386.45

Related Compounds

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