1440532-32-0

1440532-32-0 structure

Name: TWIK-1/TREK-1-IN-2
Chemical Name: TWIK-1/TREK-1-IN-2
CAS Number: 1440532-32-0
Molecular Formula: C₂₀H₂₉F₃N₂O₂
Molecular Weight: 386.45
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2023-11-04 18:24:17
Modify Date: 2024-01-16 13:06:25
TWIK-1/TREK-1-IN-2 (Compound 2g) is a TWIK-1/TREK-1 inhibitor. TWIK-1/TREK-1-IN-2 inhibits TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 10.13 μM and 15.5 μM. TWIK-1/TREK-1-IN-2 is an antidepressant[1].

Name	TWIK-1/TREK-1-IN-2

Description	TWIK-1/TREK-1-IN-2 (Compound 2g) is a TWIK-1/TREK-1 inhibitor. TWIK-1/TREK-1-IN-2 inhibits TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 10.13 μM and 15.5 μM. TWIK-1/TREK-1-IN-2 is an antidepressant[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139.

Molecular Formula	C₂₀H₂₉F₃N₂O₂
Molecular Weight	386.45