G Protein Antagonist

Names

[ Name ]:
G Protein Antagonist

[Synonym ]:
PYR-GLN-D-TRP-PHE-D-TRP-D-TRP-MET-NH2
pglu-gln-d-trp-phe-d-trp-d-trp-met-nh2
G PROTEIN ANTAGONIST
PROTEIN G ANTAGONIST 2
GP ANTAGONIST-2
pGlu-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2
[pGlu5,D-Trp7,9,10]-Substance P Fragment 5-11
G-PROTEIN ANTAGONIST-2

Biological Activity

[Description]:

G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. G-Protein antagonist peptide competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₇H₆₄N₁₂O₉S

[ Molecular Weight ]:
1093.26000

[ Exact Mass ]:
1092.46000

[ PSA ]:
362.55000

[ LogP ]:
6.16720

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding.

J. Biol. Chem. 267 , 16237, (1992)

A substance P (SP) analog, [D-Pro4,D-Trp7,9,10] SP4-11, is known to inhibit the actions of various structurally unrelated messenger molecules as well as SP. Our studies on the effects of this peptide ...