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G 28UCM

Names

[ CAS No. ]:
1094451-90-7

[ Name ]:
G 28UCM

[Synonym ]:
1,3-Naphthalenediyl bis(3,4,5-trihydroxybenzoate)
Benzoic acid, 3,4,5-trihydroxy-, 1,3-naphthalenediyl ester

Biological Activity

[Description]:

UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines[1]. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Teresa Puig, et al. A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 2011;13(6):R131.

[2]. Swayansiddha Tripathy, et al. FtsZ inhibitors as a new genera of antibacterial agents. Bioorg Chem. 2019 Oct;91:103169.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
895.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H16O10

[ Molecular Weight ]:
464.378

[ Flash Point ]:
313.3±27.8 °C

[ Exact Mass ]:
464.074341

[ LogP ]:
4.63

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.787

[ Storage condition ]:
-20°C

Related Compounds