N6-Ethyladenosine

Names

[ Name ]:
N6-Ethyladenosine

[Synonym ]:
N6-dimethylaminomethylene-O2',O3'-isopropylidene-adenosine
N6-Dimethylaminomethylen-2'-desoxy-adenosin
N6-dimethylaminomethylene-2',3'-O-isopropyldeneadenosine
N6-ethyl-adenosine
6-N-Ethyladenoside
N6-Ethyladenosine

Biological Activity

[Description]:

N6-Ethyladenosine is an adenosine derivative, acts as a Adenosine receptor agonist, with Kis of 4.9 and 4.7 nM for hA1AR and hA3AR, respectively[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

Ki: 4.9 nM (hA1AR), 4.7 nM (hA3AR)[1]

[In Vitro]

N6-Ethyladenosine (Compound 28) exhibits more selectivity at hA1AR and hA3AR over hA2AR (Ki, 8900±770 nM)[1].

[References]

[1]. Kimand SK, et al. Three-dimensional quantitative structure-activity relationship of nucleosides acting at the A3 adenosine receptor: analysis of binding and relative efficacy. J Chem Inf Model. 2007 May-Jun;47(3):1225-33. Epub 2007 Mar 6.

Chemical & Physical Properties

[ Density]:
1.76g/cm3

[ Boiling Point ]:
642.9ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₇N₅O₄

[ Molecular Weight ]:
295.29

[ Flash Point ]:
342.6ºC

[ Exact Mass ]:
295.12800

[ PSA ]:
125.55000

[ Vapour Pressure ]:
2.09E-17mmHg at 25°C

[ Index of Refraction ]:
1.778

[ Storage condition ]:
2-8℃

Related Compounds

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