14357-08-5

14357-08-5 structure

Name: N6-Ethyladenosine
Chemical Name: 2-[6-(ethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
CAS Number: 14357-08-5
Molecular Formula: C₁₂H₁₇N₅O₄
Molecular Weight: 295.29
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2016-06-12 03:04:23
Modify Date: 2024-01-10 02:17:00
N6-Ethyladenosine is an adenosine derivative, acts as a Adenosine receptor agonist, with Kis of 4.9 and 4.7 nM for hA1AR and hA3AR, respectively[1].

Name	2-[6-(ethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Synonyms	N6-dimethylaminomethylene-O2',O3'-isopropylidene-adenosine N6-Dimethylaminomethylen-2'-desoxy-adenosin N6-dimethylaminomethylene-2',3'-O-isopropyldeneadenosine N6-ethyl-adenosine 6-N-Ethyladenoside N6-Ethyladenosine

Description	N6-Ethyladenosine is an adenosine derivative, acts as a Adenosine receptor agonist, with Kis of 4.9 and 4.7 nM for hA1AR and hA3AR, respectively[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	Ki: 4.9 nM (hA1AR), 4.7 nM (hA3AR)[1]
In Vitro	N6-Ethyladenosine (Compound 28) exhibits more selectivity at hA1AR and hA3AR over hA2AR (Ki, 8900±770 nM)[1].
References	[1]. Kimand SK, et al. Three-dimensional quantitative structure-activity relationship of nucleosides acting at the A3 adenosine receptor: analysis of binding and relative efficacy. J Chem Inf Model. 2007 May-Jun;47(3):1225-33. Epub 2007 Mar 6.