Cnidicin

Names

[ Name ]:
Cnidicin

[Synonym ]:
7H-Furo[3,2-g][1]benzopyran-7-one, 4,9-bis[(3-methyl-2-buten-1-yl)oxy]-
4,9-Bis[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one

Biological Activity

[Description]:

Cnidicin is a coumarin from the root of Angelica koreana, and inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Cnidicin shows a significant inhibition upon the release of beta-hexosaminidase from the cultured RBL-2H3 cells in a dose dependent manner (IC50= 25 μM) and upon the nitric oxide production from the activated RAW264.7 cells (IC50=7.5 μM)[1].

[References]

[1]. Ryu SY, et al. Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells. Planta Med. 2001 Mar;67(2):172-4.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
519.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₂O₅

[ Molecular Weight ]:
354.396

[ Flash Point ]:
267.7±30.1 °C

[ Exact Mass ]:
354.146729

[ PSA ]:
61.81000

[ LogP ]:
6.07

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.580

[ Storage condition ]:
2-8℃

Related Compounds

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