AKI603

A novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent; disrupts normal spindle structure, and induces cell-cycle arrest; suppresses stem cell properties in breast cancer cells, and also suppresses the expression of self-renewal genes (β-catenin, c-Myc, Sox2, and Oct4); reduces xenograft tumor growth after intragastric administration.

References 1. Zheng FM, et al. Mol Cancer Ther. 2014 Aug;13(8):1991-2003. 2. Long ZJ, et al. Int J Oncol. 2015;46(6):2488-96. 3. Wang LX, et al. Sci Rep. 2016 Nov 8;6:35533. View Related Products by Target Aurora Kinase