1432515-73-5
1432515-73-5 structure
- Name: AKI603
- Chemical Name: AKI-603
- CAS Number: 1432515-73-5
- Molecular Formula: C19H23N9O2
- Molecular Weight: 409.454
- Create Date: 2020-01-20 12:47:55
- Modify Date: 2024-10-12 19:52:31
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A novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent; disrupts normal spindle structure, and induces cell-cycle arrest; suppresses stem cell properties in breast cancer cells, and also suppresses the expression of self-renewal genes (β-catenin, c-Myc, Sox2, and Oct4); reduces xenograft tumor growth after intragastric administration.
| Name | AKI-603 |
|---|
| Description | A novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent; disrupts normal spindle structure, and induces cell-cycle arrest; suppresses stem cell properties in breast cancer cells, and also suppresses the expression of self-renewal genes (β-catenin, c-Myc, Sox2, and Oct4); reduces xenograft tumor growth after intragastric administration. |
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| References | References 1. Zheng FM, et al. Mol Cancer Ther. 2014 Aug;13(8):1991-2003. 2. Long ZJ, et al. Int J Oncol. 2015;46(6):2488-96. 3. Wang LX, et al. Sci Rep. 2016 Nov 8;6:35533. View Related Products by Target Aurora Kinase |
| Molecular Formula | C19H23N9O2 |
|---|---|
| Molecular Weight | 409.454 |