IT-603

Names

[ Name ]:
IT-603

Biological Activity

[Description]:

A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays; inhibits human diffuse large B-cell lymphoma (DLBCL) cell line with IC50 of 18 uM, binds c-Rel directly and changes the conformation of the protein, inhibiting DNA binding and transcriptional activity.

[References]

References 1. Shono Y, et al. Cancer Discov. 2014 May;4(5):578-91. View Related Products by Target NF-κB

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₉BrN₂O₃S

[ Molecular Weight ]:
329.168

Related Compounds

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