verazine

Names

[ Name ]:
verazine

[Synonym ]:
(3S,8S,9S,10R,13S,14S,17R)-10,13-Dimethyl-17-[(S)-1-((S)-5-methyl-3,4,5,6-tetrahydro-pyridin-2-yl)-ethyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
Verazin, (25S)-22,26-Imino-Δ5,22,N-cholestadien-3β-ol

Biological Activity

[Description]:

Verazine ((-)-Verazine) is an anti-Fungal Agent that can be found in the dried roots and rhizoma of Veratrum maackii Regel. Verazine causes DNA damage in the cerebellum and cerebral cortex of mice in a dose-dependent manner. Verazine can be used in the study of fungal infections and neurological diseases[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Neurological Disease

[References]

[1]. Cong Y, et al. Steroidal Alkaloids from Veratrum maackii Regel with Genotoxicity on Brain-Cell DNA in Mice. Helv Chim Acta. 2015, 98(4): 539-545.

[2]. Augustin MM, et al. Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells. Plant J. 2015 Jun;82(6):991-1003.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₄₃NO

[ Molecular Weight ]:
397.64

[ Exact Mass ]:
397.33400

[ PSA ]:
32.59000

[ LogP ]:
5.86890

Related Compounds

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