FATP1-IN-1

Names

[ CAS No. ]:
1431945-95-7

[ Name ]:
FATP1-IN-1

Biological Activity

[Description]:

FATP1-IN-1 is a fatty acid transport protein 1 (FATP1) inhibitor. FATP1-IN-1 is an inhibition of recombinant human or mouse acyl-CoA synthetase activity of FATP1, with the IC50 values of 0.046 μM or 0.60 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vivo]

FATP1-IN-1 (p.o.; 10 mg/kg) treatment shows the Cmax, AUC and Tmax were 5.5 μg/mL, 36 μg h/mL and 0.33 hours, respectively, and exceeds the mouse IC50 value of 0.22 μM without considering plasma protein binding. Animal Model: Mouse plasma[1] Dosage: 10 mg/kg Administration: P.o. Result: The Cmax, AUC and Tmax were 5.5 μg/mL, 36 μg h/mL and 0.33 hours, respectively.

[References]

[1]. Matsufuji T, et al. Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg Med Chem Lett. 2013;23(9):2560-2565.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₂FN₅OS

[ Molecular Weight ]:
375.46

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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