(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate

Names

[ Name ]:
(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate

Biological Activity

[Description]:

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate) is an antagonist for Substance P (HY-P0201) and Bombesin (HY-P0195) that has effects on ocular inflammatory responses to antidromic trigeminal nerve stimulation[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[References]

[1]. A Mandahl, A Bill, et al. Effects of the substance P antagonist, (D-Arg1, D-Pro2, D-Trp7,9, Leu11)-SP on the miotic response to substance P, antidromic trigeminal nerve stimulation, capsaicin, prostaglandin E1, compound 48/80 and histamine. Acta Physiol Scand. 1984 Jan;120(1):27-35.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇₇H₁₁₂N₂₀O₁₅

[ Molecular Weight ]:
1557.84000

[ Exact Mass ]:
1556.86000

[ PSA ]:
585.51000

[ LogP ]:
7.15190

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Neuromedin B stimulates arachidonic acid release, c-fos gene expression, and the growth of C6 glioma cells.

Peptides 16 , 1133-1140, (1995)

The effects of neuromedin B (NMB) on C6 glioma cells were investigated. NMB bound with high affinity (IC50 = 1 nM) to C6 cells whereas BN and GRP were less potent (IC50 = 40 and 100 nM). NMB (1 nM) el...

A new paradigm for stem cell therapy: substance-P as a stem cell-stimulating agent.

Arch. Pharm. Res. 34 , 2003-2006, (2011)

Bone marrow is a reservoir for hematopoietic stem cells, endothelial precursor cells, and bone marrow stromal cells (also generally called mesenchymal stem cells), whose positive role in tissue repair...

Substance P mechanisms in the regulation of striated muscle microcirculation.

Microvasc. Res. 41 , 24-28, (1991)

The effects of substance P (SP) on microvessels in the cremaster of sodium pentobarbital-anesthetized male, Sprague-Dawley rats were investigated using closed-circuit television microscopy. Topically ...