Autocamtide-3

Names

[ CAS No. ]:
142828-10-2

[ Name ]:
Autocamtide-3

Biological Activity

[Description]:

Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca2+/calmodulin-dependent kinase II) (CaMK) substrate[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> CaMK
Research Areas >> Neurological Disease

[Target]

CaMK II


[In Vitro]

20 μM Autocamtide-3 (H2N-Lys-Lys-Ala-Leu-His-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-COOH), and 5 μL of CaMKII is used in a 50 μL kinase-assay reaction. Autocamtide-3 shows catalytic activity[1].

[References]

[1]. Mehtap Yilmaz, et al. Phosphorylation at Ser²⁶ in the ATP-binding site of Ca²⁺/calmodulin-dependent kinase II as a mechanism for switching off the kinase activity. Biosci Rep. 2013 Feb 7;33(2):e00024.  

Chemical & Physical Properties

[ Molecular Formula ]:
C65H113N21O20

[ Molecular Weight ]:
1508.72

Related Compounds