RORγt-IN-9a

Names

[ Name ]:
RORγt-IN-9a

Biological Activity

[Description]:

A potent, selective, CNS penetrant, orally bioavailable RORγt with pIC50 of 8.3 in FRET assays; has TH17 pEC50 of 7.3, demonstrates excellent in vivo efficacy in EAE mice.

[References]

References 1. Wang Y, et al. ACS Med Chem Lett. 2015 May 26;6(7):787-92. View Related Products by Target ROR

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₆Cl₂F₃NO₄S

[ Molecular Weight ]:
518.328

Related Compounds

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