BRD 9757
Names
[ CAS No. ]:
1423058-85-8
[ Name ]:
BRD 9757
Biological Activity
[Description]:
BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs[1].
[Related Catalog]:
[Target]
HDAC6:0.03 μM (IC50)
HDAC1:0.638 μM (IC50)
HDAC2:1.79 μM (IC50)
HDAC3:0.694 μM (IC50)
HDAC4:21.80 μM (IC50)
HDAC5:18.32 μM (IC50)
HDAC7:12.61 μM (IC50)
HDAC8:1.09 μM (IC50)
HDAC9:>33.33 μM (IC50)
[In Vitro]
BRD9757(化合物 14)对抗 HDAC1、HDAC2、HDAC3、HDAC4、HDAC5、HDAC7、HDAC8 和 HDAC9,IC50 值分别为 0.638 μM、1.79 μM、0.694 μM、21.80 μM、18.32 μM、12.61 μM、1.09 μM 和 >33.33 μM[1]。 BRD9757(化合物 14;10-30 μM;24 小时)选择性地增加 Ac-tubulin 的水平,而不增加组蛋白乙酰化[1]。 Western Blot Analysis[1] Cell Line: HeLa cells Concentration: 10 μM and 30 μM Incubation Time: for 24 h Result: Increased the level of Ac-tubulin.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C6H9NO2
[ Molecular Weight ]:
127.14100
[ Exact Mass ]:
127.06300
[ PSA ]:
49.33000
[ LogP ]:
0.99300
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H319-H412
[ Precautionary Statements ]:
P273-P305 + P351 + P338
[ RIDADR ]:
NONH for all modes of transport