BRD 9757

Names

[ Name ]:
BRD 9757

Biological Activity

[Description]:

BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC6:0.03 μM (IC50)

HDAC1:0.638 μM (IC50)

HDAC2:1.79 μM (IC50)

HDAC3:0.694 μM (IC50)

HDAC4:21.80 μM (IC50)

HDAC5:18.32 μM (IC50)

HDAC7:12.61 μM (IC50)

HDAC8:1.09 μM (IC50)

HDAC9:>33.33 μM (IC50)

[In Vitro]

BRD9757（化合物 14）对抗 HDAC1、HDAC2、HDAC3、HDAC4、HDAC5、HDAC7、HDAC8 和 HDAC9，IC50 值分别为 0.638 μM、1.79 μM、0.694 μM、21.80 μM、18.32 μM、12.61 μM、1.09 μM 和 >33.33 μM[1]。 BRD9757（化合物 14；10-30 μM；24 小时）选择性地增加 Ac-tubulin 的水平，而不增加组蛋白乙酰化[1]。 Western Blot Analysis[1] Cell Line: HeLa cells Concentration: 10 μM and 30 μM Incubation Time: for 24 h Result: Increased the level of Ac-tubulin.

[References]

[1]. Florence F Wagner, et al. Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J Med Chem. 2013 Feb 28;56(4):1772-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₉NO₂

[ Molecular Weight ]:
127.14100

[ Exact Mass ]:
127.06300

[ PSA ]:
49.33000

[ LogP ]:
0.99300

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319-H412

[ Precautionary Statements ]:
P273-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.