N-Acetyl-D-galactosamine

Names

[ Name ]:
N-Acetyl-D-galactosamine

[Synonym ]:
N-[(3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]acetamide
EINECS 217-321-9
MFCD00065372
D-Galactopyranose, 2-(acetylamino)-2-deoxy-
N-ACETEYL-D-GALACTOSAMINIDE
N-Acetyl-D-galactosamine
2-(Acetylamino)-2-deoxy-D-galactopyranose
N-acelyl-D-glucosamine
2-Acetamido-2-deoxy-D-galactose
N-Acetylchondrosamine
N-ACETYL-D-GALACTOSAMINIDE
N-((3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide
2-Acetamido-2-deoxy-D-galactopyranose Hydrate
2-Acetamido-2-deoxy-D-galactopyranose
ACETYL-D-GALACTOSAMINE
N-Acetyl-D-chondrosamine Hydrate

Biological Activity

[Description]:

N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets[1].N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin[2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) decreases the expression of occludin mRNA and claudin-3 mRNA by 1.6% and 2.7%[1]. N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) lowers the protein expression of occludin and claudin-3 by 4.3% and 7.2%, respectively[1]. RT-PCR[1] Cell Line: IPEC-J2 cell Concentration: 50 nM Incubation Time: 4 hours Result: Observed a slight reduction in mRNA expression of occludin and claudin-3. Western Blot Analysis[1] Cell Line: IPEC-J2 cell Concentration: 50 nM Incubation Time: 4 hours Result: Alleviated the damage of tight junction expressions at protein level.

[References]

[1]. Zhao B, et al. N-Acetyl-d-galactosamine prevents soya bean agglutinin-induced intestinal barrier dysfunction in intestinal porcine epithelial cells. J Anim Physiol Anim Nutr (Berl). 2019 Jul;103(4):1198-1206.

[2]. Sadanandan R, et al. Isolation, Purification and Characterisation of a D-galactose and N-acetyl-D-galactosamineSpecific Lectin from Marine Sponge Fasciospongia cavernosa. Protein Pept Lett. 2018;25(9):871-877.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
595.4±50.0 °C at 760 mmHg

[ Melting Point ]:
158-162 °C

[ Molecular Formula ]:
C₈H₁₅NO₆

[ Molecular Weight ]:
221.208

[ Flash Point ]:
313.9±30.1 °C

[ Exact Mass ]:
221.089935

[ PSA ]:
119.25000

[ LogP ]:
-2.48

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.576

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

Related Compounds

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