Piperazine adipate

Names

[ CAS No. ]:
142-88-1

[ Name ]:
Piperazine adipate

[Synonym ]:
PIPERAZINE ADIPATE
hexanedioic acid,piperazine
EINECS 205-569-0
MFCD00050650

Biological Activity

[Description]:

Piperazine adipate is a potent broad spectrum anthelmintic against many common worm infections in mammals.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[In Vitro]

Piperazine adipate (10 mM) causes mortality of A. galli and H. gallinae after a maximum of 30 min exposure, inhibits malate oxidation by 78%, and inhibits aldolase activity in both parasites. Piperazine adipate (10 mM) also inhibits cholinesterase activity by 96% in Ascaridia galli (A. galli) and 93% in Heterakis gallinae (H. gallinae). Piperazine adipate inhibits oxaloacetate reduction by 26% and 55% in A. galli and H. gallinae, resepctively[1].

[References]

[1]. Sharma RK, et al. Effect of parbendazole and piperazine adipate on the activity of some enzymes of Ascaridia galli and Heterakis gallinae. Vet Parasitol. 1987 May;24(3-4):211-20.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
338.5ºC at 760 mmHg

[ Melting Point ]:
250ºC (Decomposes)

[ Molecular Formula ]:
C₁₀H₂₀N₂O₄

[ Molecular Weight ]:
232.27700

[ Flash Point ]:
172.7ºC

[ Exact Mass ]:
232.14200

[ PSA ]:
98.66000

[ LogP ]:
0.55280

[ Vapour Pressure ]:
1.81E-05mmHg at 25°C

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents. May be light-sensitive.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MO1955000

CAS REGISTRY NUMBER :: 142-88-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H10-O4.C4-H10-N2

MOLECULAR WEIGHT :: 232.32

WISWESSER LINE NOTATION :: T6N DNTJ &QV4VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 13,539,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,100,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,100,1982

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
MO1955000

[ HS Code ]:
2933599090

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

The effect of piperazine adipate and parbendazole on the carbohydrate metabolism of Ascaridia galli and Heterakis gallinae.

Angew. Parasitol. 28(4) , 207-10, (1987)

Carbohydrate metabolism of Ascardia galli and Heterakis gallinae was studied after their exposure in vitro to 10(-2) to 10(-5) M piperazine adipate and parbendazole for 10 to 60 min. Following treatme...

[Study of compounds with potential antiparasitic effect. V. Antihistaminics].

Wiad. Parazytol. 26(1) , 59-64, (1980)

[Experience with the prevention of enterobiasis in children from preschool institutions of the Zhitomir district].

Pediatriia (7) , 82-3, (1990)