NSC 625987

Names

[ CAS No. ]:
141992-47-4

[ Name ]:
NSC 625987

[Synonym ]:
1,4-Dimethoxy-9-thio(10H)-acridone
Tocris-2152

Biological Activity

[Description]:

NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK4/D1:0.2 μM (IC50)

[In Vitro]

NSC 625987 (10 nM, 50 nM, 100 nM) treatment attenuates the enhanced proliferation of vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) rats by about 35%[2].

[References]

[1]. A Kubo, et al. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999 Dec;5(12):4279-86.

[2]. Jasmine El Andalousi, et al.Natriuretic peptide receptor-C agonist attenuates the expression of cell cycle proteins and proliferation of vascular smooth muscle cells from spontaneously hypertensive rats: role of Gi proteins and MAPkinase/PI3kinase signaling. PLoS One. 2013 Oct 14;8(10):e76183.

Chemical & Physical Properties

[ Density]:
1.32g/cm3

[ Boiling Point ]:
460.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₃NO₂S

[ Molecular Weight ]:
271.33400

[ Flash Point ]:
232.2ºC

[ Exact Mass ]:
271.06700

[ PSA ]:
66.34000

[ LogP ]:
4.06780

[ Vapour Pressure ]:
1.17E-08mmHg at 25°C

[ Index of Refraction ]:
1.683

MSDS

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Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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